Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling
Vascular calcification is prominent in patients with chronic kidney disease (CKD) and is a strong predictor of cardiovascular mortality in the CKD population.However, the mechanism underlying CKD-associated vascular calcification remains unclear.To identify potential therapeutic targets, a 5/6 nephrectomy rat model was established by feeding of a h