SCLEROSTIN IS INVOLVED IN OSTEOGENIC TRANSDIFFERENTIATION OF VASCULAR SMOOTH MUSCLE CELLS IN CHRONIC KIDNEY DISEASE-ASSOCIATED VASCULAR CALCIFICATION WITH NON-CANONICAL WNT SIGNALING

Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling

Vascular calcification is prominent in patients with chronic kidney disease (CKD) and is a strong predictor of cardiovascular mortality in the CKD population.However, the mechanism underlying CKD-associated vascular calcification remains unclear.To identify potential therapeutic targets, a 5/6 nephrectomy rat model was established by feeding of a h

read more




Supervised learning and model analysis with compositional data.

Supervised learning, such as regression and classification, is an essential tool for analyzing modern high-throughput sequencing data, for example in microbiome research.However, due to the compositionality and sparsity, existing techniques are often inadequate.Either Mirrorless Lens they rely on extensions of the linear log-contrast model (which a

read more